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Peter F Kador Selected Research

Sorbitol (Yal)

2/2014Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus.
8/2012Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation.
6/2011Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
4/2011Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats.
5/2010Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats.
8/2004Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor.
4/2003Diabetes can alter the signal transduction pathways in the lens of rats.

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Peter F Kador Research Topics

Disease

18Cataract (Cataracts)
08/2021 - 04/2003
8Diabetic Retinopathy (Retinopathy, Diabetic)
01/2016 - 11/2006
6Hyperglycemia
01/2016 - 08/2004
3Diabetes Mellitus
02/2014 - 11/2006
2Mitochondrial Diseases (Mitochondrial Disease)
08/2021 - 01/2015
2Alzheimer Disease (Alzheimer's Disease)
11/2015 - 01/2015
2Periodontitis
06/2011 - 05/2010
2Alveolar Bone Loss
06/2011 - 05/2010
2Retinal Neovascularization
04/2007 - 12/2003
1Noise-Induced Hearing Loss (Acoustic Trauma)
08/2021
1Hearing Loss (Hearing Impairment)
08/2021
1Vision Disorders (Hemeralopia)
08/2021
1Wounds and Injuries (Trauma)
11/2019
1Diabetes Complications
01/2016
1Neuroblastoma
11/2015
1Neurodegenerative Diseases (Neurodegenerative Disease)
11/2015
1Macular Degeneration (Age-Related Maculopathy)
01/2015
1Dry Eye Syndromes (Dry Eye Syndrome)
09/2014
1Inflammation (Inflammations)
03/2011
1Ischemia
02/2011
1Starvation
02/2011
1Infections
05/2010
1Corneal Edema
04/2007
1Mydriasis
04/2007
1Hypoglycemia (Reactive Hypoglycemia)
11/2006
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2006
1Body Weight (Weight, Body)
10/2006
1Eye Diseases (Eye Disease)
12/2003
1Galactosemias (Galactosemia)
06/2002
1Microaneurysm
06/2002

Drug/Important Bio-Agent (IBA)

13Aldehyde Reductase (Aldose Reductase)IBA
01/2016 - 06/2002
11Retinaldehyde (Retinal)IBA
11/2015 - 06/2002
11Galactose (Galactopyranose)FDA LinkGeneric
03/2011 - 06/2002
8SugarsIBA
08/2012 - 04/2003
7Sorbitol (Yal)FDA Link
02/2014 - 04/2003
6Streptozocin (Streptozotocin)FDA Link
09/2014 - 08/2004
3MetalsIBA
08/2021 - 01/2015
3Proteins (Proteins, Gene)FDA Link
11/2019 - 01/2011
3AntioxidantsIBA
11/2015 - 04/2011
3imirestatIBA
06/2011 - 05/2010
2Reactive Oxygen Species (Oxygen Radicals)IBA
08/2021 - 11/2015
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2012 - 03/2011
2LipopolysaccharidesIBA
06/2011 - 05/2010
2EnzymesIBA
03/2011 - 11/2006
2polyolIBA
03/2011 - 08/2004
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
03/2011 - 04/2009
2Glucose (Dextrose)FDA LinkGeneric
02/2011 - 09/2006
2Pharmaceutical PreparationsIBA
03/2010 - 04/2007
1Reactive Nitrogen SpeciesIBA
08/2021
1Adenosine Triphosphatases (ATPase)IBA
11/2019
1Ouabain (G Strophanthin)IBA
11/2019
1OxysterolsIBA
11/2019
1Liposomes (Liposome)IBA
11/2019
125-hydroxycholesterolIBA
11/2019
1Bicarbonates (Hydrogen Carbonate)IBA
11/2019
1LanosterolIBA
11/2019
1Crystallins (Crystallin)IBA
11/2019
1Glutathione (Reduced Glutathione)IBA
11/2015
1Chelating AgentsIBA
11/2015
1Hydroxyl RadicalIBA
11/2015
1Clioquinol (Vioform)FDA Link
11/2015
1Amyloid (Amyloid Fibrils)IBA
01/2015
1Scopolamine (Hyoscine)FDA Link
09/2014
1Green Fluorescent ProteinsIBA
02/2014
1GalactitolIBA
08/2012
1tolrestatIBA
06/2011
1QuercetinIBA
06/2011
1Free RadicalsIBA
04/2011
1Xylose (D-Xylose)FDA Link
04/2011
1Advanced Glycation End ProductsIBA
03/2011
1Mitogen-Activated Protein KinasesIBA
03/2011
1Protein Kinase CIBA
03/2011
1Endoplasmic Reticulum Chaperone BiPIBA
02/2011
1Immunoglobulins (Immunoglobulin)IBA
02/2011
1Messenger RNA (mRNA)IBA
01/2011
1Poly(ADP-ribose) Polymerase InhibitorsIBA
04/2009
1Selenious Acid (Selenite)IBA
08/2007
1ursodoxicoltaurineIBA
08/2007
1trimethyloxamine (trimethylamine N-oxide)IBA
08/2007
1fosbretabulin (combretastatin A4)IBA
04/2007
1ProdrugsIBA
04/2007
1SuspensionsIBA
04/2007
1L-Iditol 2-Dehydrogenase (L Iditol 2 Dehydrogenase)IBA
08/2004
1Fluorescein (Funduscein)FDA LinkGeneric
12/2003

Therapy/Procedure

4Lenses
11/2019 - 09/2006
3Slit Lamp
09/2014 - 10/2006
3Injections
09/2014 - 05/2010
3Therapeutics
04/2011 - 12/2003
2Oral Administration
08/2021 - 08/2004
2Topical Administration
11/2010 - 10/2006
1Glycemic Control
01/2016
1Intraocular Injections
04/2007